Interesting to see that there is scientific research into the connection between emotions and physical effects.
Shame has distinct physiological effects across bodily systems. It activates the sympathetic nervous system, increasing heart rate, blood pressure and skin conductance. Intense or chronic shame may trigger a parasympathetic ‘freeze’ response, with reduced heart rate variability and emotional numbing. It is linked to elevated cortisol (via the hypothalamic–pituitary–adrenal axis), reflecting prolonged stress and reduced vagal tone, which impairs emotional regulation and social engagement. Gastrointestinal symptoms such as nausea or stomach tightness point to gut–brain axis involvement. When persistent, shame may drive inflammation and metabolic dysregulation, contributing to depression, obesity and autoimmune conditions.
- British Journal of Psychiatry